The BioInformer nr. 3, 1998 -- Pfam 2.1




	A publication of EMBL - Outstation Hinxton, The European Bioinformatics Institute


		Pfam 2.1 Introduction Pfam is a large collection of protein domain family alignments which were constructed semi-automatically using profile hidden Markov models (HMMs's). Pfam families contain functional annotation and cross-references to other databases. A paper on Pfam has been published in Proteins 28:405-420 (1997). Pfam was recently mentioned in the Science Genome issue (Vol 278, No 5338). This issue includes a poster about characterising gene families using a variety of methods, including Pfam. Availability Release 2.1 contains new annotation and corrections to some families compared to release 2.0. Pfam 2.1 is available on the web, offering access to multiple sequence alignments and profile HMM searches. Written by: Ewan Birney Resources and further information Sanger Centre http://www.sanger.ac.uk/ Pfam home page (UK) http://www.sanger.ac.uk/Pfam/ Pfam database ftp site ftp://ftp.sanger.ac.uk/pub/databases/Pfam/ Washington University http://www.wustl.edu/ Genetics Department http://genome.wustl.edu/ Pfam homepage (USA) http://genome.wustl.edu/Pfam/ Pfam database ftp site ftp://genome.wustl.edu/pub/databases/Pfam/ External sites are not endorsed by EMBL-EBI

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