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Genes Network Database Introduction GeNet is a specialised database which contains the information on functional organisation of regulatory genes networks acting at embryogenesis. The regulatory genes play a crucial role in embryogenesis, controlling both activity of downstream regulatory genes (crossregulation), as well as their own activity (autoregulation). These are the autoregulatory and crossregulatory functional links, which unite the regulatory genes in gene networks. Most genes of network encode a peptide products - so called transcription factors, whose function is activation or repression of downstream target genes. Down-activated members of network in turn switch on structural genes at the appropriate time and place. The structural genes produce enzymes for subsequent differentiation and morphogenesis of embryo rudiments. Thus the network of regulatory genes defines the genome activity during embryo development. It is evident, that to reveal the mechanisms of embryogenesis it is necessary to understand the principles of regulatory genes networks organisation. Availability GeNet is accessible through a web interface at the Biological Information Systems Lab of the Institute for High-Performance Computing and Data Bases (IHPCDB) in St. Petersburg, Russia, or as a interactive Java applet. Information provided by: Alexander V. Spirov Resources and further information
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Direct questions or comments to Bioinformer Editor. This page last modified Friday, 16 July, 1999. (c) 1997-1999 EMBL-EBI. All Rights Reserved. |